Domain Arrivals
You’re viewing the 2026-08-18 issue, not the current issue. Go to the current issue: 2026-09-11

Featured in Domain Arrivals · 2026-08-18

Oncyra turns TP53 variants into rescue hypotheses

oncyra.com ↗ · Developer Corner · score 84.0
○Open: public page gives enough substance to understand the site $Paid: pricing, booking, ecommerce, subscription, or paid access is visible ADAds: visible ad load or ad-supported content ✦Pretty: notable design, copy, craft, or presentation ◆Pro: polished, finished-feeling, serious, or operationally mature ◇Niche: specific audience, workflow, or unusually focused use case ◉Human: personal, local, community, civic, handmade, or real-person signal !Suspicious: scammy, spammy, trust theater, finance fog, or credibility concern

A mutation-aware research workspace for moving from a TP53 variant to an evidence-linked shortlist of possible rescue compounds.

Why it surfaced

Oncyra searches the public ChEMBL bioactivity archive for variant-specific and same-residue measurements, including cited Kd, Ki, IC50, and EC50 values. Its screening workflow covers roughly 4,000 TP53 profiles and 3,311 approved drugs, while explicitly distinguishing measured binding from docking predictions.

Read the complete issue Observed source ↗

Continue into the edition

The Plotter’s 09:30 Shift

August 18’s newborn domains include an obsolete pen plotter clocking in at 09:30, emergency warnings designed for sight, touch, or hearing, a funeral-folder tool calibrated for printer drift, and photographs of Colombian rental signs turned into a housing map.

This is one of 1,000 discoveries in the 2026-08-18 Domain Arrivals issue.

Explore the complete issue Browse Developer Corner

More from Developer Corner

Three more arrivals

BlackPlastic Design blackplasticdesign.com

A board-level repair reference for Blackmagic cinema cameras, with component lookup, package maps, fault investigations, and repair-focused documentation.

 Avzi Labs: Spectrum Auctions, Games, and Useful Oddities avzilabs.com

A personal engineering site featuring spectrum-auction platforms, auction simulations, multiplayer games, data tools, writing, and live demos.

 Orbitope — Constrained Creativity orbitope.com

A collection of interactive essays, browser experiments, games, and developer tools about machine learning, game development, optimization, and generative systems.