Observed arrival · 2026-09-07
TrueLocus | Resolving Distal Non-Coding Screen Hits
A computational audit service that ranks likely target genes for ambiguous non-coding CRISPRi hits and GWAS loci without requiring cell-type Hi-C.
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The page frames target-gene assignment as a distinct liability after a non-coding screen: the hit coordinate may be known while the causal promoter remains uncertain. Its stated benchmark compares sequence-plus-CAGE ranking against nearest-TSS and Broad ABC, with the latter requiring K562 Hi-C, ChIP, and ATAC data. TrueLocus says its audit turns around in 14 days and is intended for settings where cell-type Hi-C is absent or impractical.
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