Observed arrival · 2026-09-18
Cure’s Open Screening Ledger
An open computational-screening project tests molecules against neglected-disease targets and publishes the failures alongside the results.
- For
- Open-science researchers and neglected-disease investigators
- Worth noticing
- The project fixes an AUC-ROC pass mark of 0.70 before each run and publishes rejected targets.
Field notes
The workflow begins by filtering protein structures and testing whether docking can recover known poses. Cure then evaluates real laboratory inhibitors against chemically matched presumed-inactive decoys, with the 0.70 AUC-ROC threshold fixed before seeing results. The page says two targets have already failed validation and that their rejection numbers are published. It also commits to recording seeds, software versions, GPU rental costs, and the full score of each screened molecule.
Observed signals
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Editorial observations of this landing page, not a rating.
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