Observed arrival · 2026-10-21
AOPEDEX maps endocrine-disruption predictions across species
A searchable research database connects chemical activity and species traits to predicted endocrine-disruption mechanisms.
- For
- Ecotoxicology researchers selecting species and mechanisms for follow-up
- Worth noticing
- The reference panel tracks conservation across 12 receptor-binding pockets and spans 756 species.
Field notes
AOPEDEX combines ToxCast compound activity, receptor-pocket conservation, and phylogenetic relatives within an AOP event network. Its displayed species panel covers 756 species across eight vertebrate groups; the site says 714 currently yield predictions, including 123 of 138 threatened species, with 38 marked high-confidence. Outputs are framed as mechanistic hypotheses and screening priorities for experimental follow-up, not substitutes for species-specific toxicity data. The page names AOP-Wiki, EPA ToxCast, TimeTree, NCBI, ECOTOX, UniProt, PubChem, and IUCN as data sources.
Observed signals
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