Observed arrival · 2026-11-02
retro-lm’s live retrosynthesis bench
A browser playground for testing a 0.6B chemistry model that proposes reactants for a molecule or searches for a full synthesis route, with comparisons to frontier LLMs.
○Open
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✦Pretty
●Pro
◎Niche
◉Human
⚑Risk
ƒJS
- For
- Chemistry researchers and model evaluators comparing retrosynthesis systems
- Worth noticing
- Route search uses Retro* and a 23-million-molecule purchasable catalogue, with a call budget and 60-second limit.
Field notes
Benchmark mode compares each model’s proposal with reactants recorded in patents, after canonicalizing both sides with RDKit. The page notes that chemically valid alternatives still count as misses, making reported accuracy a lower bound; its cost and timing comparisons also distinguish benchmark hardware from the live deployment.
Observed signals
Read the marks
Editorial observations of this landing page, not a rating.
○OpenPublic substance visible
✦PrettyNotable craft visible
●ProPolished or operationally mature
◎NicheUnusually specific use
One card from the complete issue