Observed arrival · 2026-09-30
The Amyloid Heart
An illustrated, interactive tutorial traces cardiac amyloidosis from protein misfolding to imaging clues and the non-invasive diagnostic work-up.
- For
- Clinicians and learners studying cardiac amyloidosis
- Worth noticing
- Its timeline places carpal tunnel syndrome 5–9 years before diagnosis and the first heart-failure diagnosis a median 494 days before ATTR diagnosis.
Field notes
The page links the biology to specific clinical findings: a steep diastolic pressure-volume curve, restrictive mitral inflow, low tissue-Doppler velocities, and relative apical sparing on strain imaging. Its work-up section lays out four combinations of monoclonal-protein screening and bone scintigraphy with SPECT. A separate section describes an echo-reading system and compares flags and missed cases across 1,000 echocardiograms, including simulated performance pairs.
Observed signals
Read the marks
Editorial observations of this landing page, not a rating.
One card from the complete issue