Observed arrival · 2026-10-22
GigaPRS: polygenic risk scores across ancestries
GigaPRS builds polygenic risk scores from summary statistics across GWAS, with browser-based and command-line workflows.
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- Genetics researchers working with GWAS summary statistics
- Worth noticing
- Its stepwise method keeps a secondary GWAS only when it raises effective sample size by at least 5%.
Field notes
The method first combines a target-trait GWAS with selected summary statistics from genetically correlated traits, then estimates ancestry-specific SNP effects. Its stated 5% effective-sample-size threshold determines whether a secondary set is kept. The page also provides LDAK command-line examples and describes ancestry-proportion weighting for target individuals; it says the browser workflow runs its first step locally.
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